5-MeO-MIPT, or 5-methoxy-N-methyl-N-isopropyltryptamine also known as “Moxy” is a psychedelic and entactogenic drug in a class of compounds commonly known as tryptamines. It is the N-methyl-N-isopropyl homologue of the well know psychedelic 5-MeO-DMT. It has structural and pharmacodynamic properties similar to the drugs 5-MeO-DiPT, DiPT, and MiPT .
This substance has no history of human usage prior to the 1985 publication of its synthesis and pharmacology in the Journal of Medicinal Chemistry by Repke, Grotjahn, & Shulgin. In modern times it is used as a recreational drug and an entheogen, rarely sold on the streets and almost exclusively obtained as a grey area research chemical through the use of online vendors.
The mechanism that produces the hallucinogenic and entactogenic effects of 5-MeO-MiPT is thought to result primarily from 5-HT2A receptor agonism, although additional mechanisms of action such as inhibition of MAO may also be involved.
The 5-MeO-MiPT experience contains a complex and wide array of effects which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe.
The physical effects of 5-MeO-MIPT can be broken down into three components all of which progressively intensify proportional to dosage. These are described below and generally include:
Spontaneous tactile sensations – the body high of 5-MeO-MIPT can be described as a pleasurable, warm, soft and all encompassing glow. There is also a cold, sharp tingling sensation that is manifested spontaneously at different unpredictable points throughout the trip but for others it can maintain a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
Stimulation and Sedation – in terms of its effects on the physical energy levels of the tripper, 5-MeO-MIPT can be both sedating and stimulating. The physical energy levels seem to manifest themselves in waves in an unpredictable pattern. This seems to be partially setting dependant and during physically strenuous situations such as running or dancing it can become stimulating and energetic. In contrast however, in calm environments such as darkened rooms with comfortable seating it can become relaxing, peaceful and even moderately sedating.
Nausea – as the tripper begins to come up, nausea is not uncommon and can sometimes result in initial vomiting, but passes once this over or the trip begins to fully set in. In comparison to other psychedelics such as psilocin, LSD, and 2C-E, this could actually be very considered very mild in its intensity. In comparison to 5-MeO-DIPT, this substance has a much lower tendency to trigger unpleasant physical reactions and has been described as much less physically stimulating.
The head space of 5-MeO-MIPT is described by many as one which is both insightful and moderately relaxing, but at some points quite stimulating. This substance produces a large number of general psychedelic cognitive effects. The most prominent of these effects generally include:
Introspection – this component is consistently manifested only in the context of a non social setting in which the user is alone.
Increased empathy, love and sociability – this component is consistently manifested only in the context of social settings in which one is within the company of others. These feelings of sociability, love and empathy are a little weaker and less sharp than those found on substances such as MDMA and 2C-B but still prove strong enough to provide long lasting therapeutic effects.
Acceleration of thought
Connectivity of thought
Feelings of fascination, importance and awe
Enhancement of current mind state
Removal of cultural filter
Ego suppression, loss and death
5-MeO-MIPT presents a complete array of possible visual enhancements which generally include:
Increased visual acuity
Enhancement of colours
Enhanced pattern recognition
As for visual distortions and alterations, these generally include:
Visual drifting (melting, breathing, warping and flowing) – In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion and static in appearance.
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of psilocin, 4-AcO-DMT, or ayahuasca than that of LSD or 2C-B. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, equal in blurred and sharp edges, and equal in rounded and angular corners. At higher dosages, they are significantly more likely to result in states of level 7B visual geometry over level 7A.
In terms of their manifesta .